Rejuran S Acne Scar Treatment

Rejuran S At A Glance

  • Best Results2-4 sessions
  • Treatment Recovery1-2 days
  • Procedure Time5 minutes
  • Skin SpecialistNurse, Dermatologist
  • Duration of ResultsPermanent
  • AnaestheticGel & or local aesthetic
  • Back to Work Immediately - 36 hours
  • Cost$-$$

Rejuran S Acne Scar Treatment

Rejuran S is new for 2023 as an acne scar treatment. This injectable is a permanent solution for superficial acne scars. Rejuran S contains DNA fragments called polynucleotides which are injected into the deeper layers of scar tissue. Polynucleotides stimulate your cells to produce collagen. Unlike lasers, recovery from Rejuran S is superfast- typically less than 48 hours. 

FactsFacts on Rejuran S Acne Scar Treatment

  • This injectable treatment is suitable for superficial acne scars & skin rejuvenation
  • Rejuran S contains a DNA derived compound known as polynucleotide
  • Polynucleotides actives your cells to produce collagen
  • Unlike lasers Rejuran has little to no recovery time
  • Treatments are well tolerated & take less than 5 minutes to perform
  • 2-4 sessions are required for best results

What is Rejuran S & how does it work for scar removal?

Rejuran S is a novel treatment for acne scars, introduced into Australia in 2023. It has a long safety record in Asia & Europe spanning over 5 years. 

Rejuran contains salmon DNA known as polynucleotide. This compound is injected into the scar tissue. It degrades over time & stimulates cells known as fibroblasts. This in turn produces new collagen. Collagen fills in the holes of acne scars. 

Is the treatment painful?

Treatments are well tolerated as we –

  1. Combine injections with local aesthetic mix in with Rejuran S.
  2. Use numbing cream prior to treatment.

Treatment time is less than 5 minutes. 

How many sessions are required?

2-4 depending on the severity & extent of your scarring. Most patients will see results following 1-2 sessions. Best results are seen 2-3 months after the last session. 

Are the results permanent?

Yes. Unlike dermal fillers which fill the void of collagen loss, Rejuran harnesses your skin’s natural ability to rejuvenate collagen. Once scars are corrected, it is extremely unlikely that they will revert to their natural state. Read more to understand the role of Rejuran, including pros & cons. 

How does Rejuran differ from dermal fillers for acne scars?

Think of dermal fillers as putty for filling up the holes of acne scarring. Dermal fillers are usually placed in the sub-dermal zone, namely in the fat. Over time they degrade (usually 1-4 years, depending on the filler & your metabolism). 

Rejuran is a biostimulator. It is placed in the dermal layer of skin (higher up than dermal fillers). Unlike dermal fillers, the results from Rejuran are slower as it relies on your immune system to generate collagen. The flipside? Once corrected, the results are permanent. 


What types of acne scars respond to Rejuran injectables?

Rejuran is indicated for superficial low volume atrophic scar types, including box car scars as well as shallow rolling acne scars. 

The following scars do not respond well to Rejuran as they lie deeper in the skin. 

  • Subdermal atrophic scars: best treated with subcision & collagen stimulating injectables, RFM, deep fractional lasers
  • Deep rolling scars: treatment with subcision & dermal fillers
  • Ice pick scars: best removed with punch excision, TCA CROSS

Davin’s viewpoint on Rejuran S for acne scars

The future of acne scar removal is in the biostimulatory injectable realm. Why? Injectables work by stimulating the natural responses of  skin to correct atrophy by removing acne scars & or stimulating the production of collagen, elastin, & hyaluronic acid. The prospect of biostimulation is exciting because unlike traditional acne scar revision methods such as lasers & TCA peels, injectables have little, if any downtime. As we are targeting the deeper layers of skin, recovery is less than 48 hours. 

This injectable consists of polynucleotide- extracted DNA derived from salmon gonads. Polynucleotide functions in two ways. Firstly, it provides a scaffolding for collagen to ‘hang on’ to. Secondly it acts to stimulate production of collagen. 

The two rate limiting prospects of Rejuran S are –

  1. Can your immune system be stimulated by polynucleotide? Here is the catch- it is called the gaussian curve, namely the sum of a large number of independent and identically distributed random variables will tend to be normally distributed, regardless of the distribution of the individual variables. Hence some will lie to the right of the median (excellent stimulation), whilst a proportion of others may lie to the very left (poor stimulation). As we are relying on your immune system to generate collagen, this is another variable we need to consider- unlike dermal fillers (which may function as ‘putty’ or bog). 
  2. If you can generate collagen, will it be enough to fill up the atrophy? This is where the volumetric defect of the acne scar itself has to be taken into account. Rejuran S is hence best employed for small volume defects- box car scars are an example of this. For larger areas of subdermal atrophy (where fat loss is significant), the use of traditional fillers (or fat transfer), placed in the deeper layers of skin will give more predictable results. 

In summary, Rejuran S is a useful modality that requires very little skill and can give good results in most superficial acne scar types. Outcomes are dependent on identifying the suitable candidate, in addition to relying on your body’s immune response to correct atrophy. It is thus a useful modality that can be integrated into the current repertoire of scar revision. 

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