Rigenera for scars

  • Best Results18-24 months
  • Treatment Recovery0 days
  • Procedure Time15 minutes
  • Skin SpecialistDr Davin Lim
  • Duration of Results Long-term
  • AnaestheticNumbing to sedation
  • Back to WorkImmediately
  • Cost$$-$$$

Rigenera for scars

Regenera Activa & Rigenera is a device that uses autologous micrografts harvested from the patient’s skin. These grafts are then re-injected into areas of pathology, including acne scars, dermal scarring, as well as keloid scarring. Over time scars are remodelled using your own stem cells. Treatments are quick with little or no downtime. Read more to understand the concepts behind this treatment.

FactsFacts on Rigenera for Scars

  • This is a form of non-cultured autologous cellular grafting
  • This means donor tissue is harvested from your skin then processed
  • Processed tissue contains dermis, fat, fibroblasts, hyaluronic acid & stem cells
  • This is also a natural source of growth factors & cytokines
  • This solution is then re-injected into the areas of scarring
  • Scar remodelling takes place over 12 to 24 months
  • Scar types amenable to Rigenera include atrophic, keloid, hypertrophic & mixed scars due to acne, trauma, burns, & surgery

What is Rigenera?

This is a novel treatment for a variety of skin conditions including acne scars, traumatic, keloid scars, burns & hair loss. It is also used to address age related reduction in collagen & dermal matrix. It uses the concept of micrografting dermal components of skin.

What is the science behind stem cell therapy, Rigenera & Regenera Activa?

The theory behind micrografting & stem cells is that transfer of normal dermal matrix (including fat) causes wound repair cascade. Mesenchymal stem cells can, in theory secrete growth factors, cytokines & chemokines to repair scar tissue & wounds. They can increase blood vessels (angiogenesis), reduce inflammation & promote migration & induction of collagen producing cells known as fibroblasts.

What types of scars can be treated with Rigenera?

Ideally, small areas of atrophic scars have the potential to remodel with Rigenera. Remember, with published studies, it can take up to 2 years to see the best results.

Studies have shown that the following types of scars can potentially respond to micrografting- atrophic scars, hypertrophic & keloid scars, red scars, & hypopigmented scars. 

When are the results seen?

In the context of dermal remodelling, results are slow. Studies have shown some improvement is seen at 6 months, more at 12 months, & maximal at 24 months. Therefore I normally recommend a combination of treatments including lasers, peels, PRP (in the context of synergistic treatments) as well as surgical procedures including subcision & excision.

Davin’s Viewpoint on Rigenera

Rigenera is not a new treatment, having been on the scene for nearly a decade. It also goes by the name of Regenera Activa. In essence it is a dermal graft that is cut into small bits with microblades within the device itself. Normal dermal grafts are about 0.5 to 1.5 mm in diameter. Rigenera dermal grafts are 50 to 80 microns or 5/100 to 8/100 of a millimeter.

Studies in the context of scars are few & consist of a small series of treatment. To date (in 2022), there are no split placebo (saline) studies on scars. This means blinded large number studies where half the scar is treated with normal saline & the other half with Rigenera. Regardless, it can be useful as adjunctive therapy for small volume deficits.

Moderate to severe atrophic scars whereby tissue loss in both dermal and subcutaneous may have a real time volume deficit of 5 to 10 millilitres. This is substantially more than say 20-30 2.5 mm punch grafts. In this context it is highly unlikely that mesenchymal stem cells derived from dermal punches (even if they contain a small amount of mesenchymal adipose stem cells), can differentiate into cells such as fibroblasts.

If you think that this treatment is for you, please note that it can take up to 2 years before you see the best results. Regardless of the paucity of research, this has some merit (as dermal grafts do work). If patients are risk averse to potential dermal filler complications & would like a non-cultured cellular graft, consider Rigenera.


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