Hydroxypinacolone Retinoate HPR Granactive Retinoid

Hydroxypinacolone Retinoate HPR Granactive Retinoid

Best used: PMCaution: Sensitive Skin, RosaceaBest for: Anti-aging, acne
Comments: Early development. Retinoid effects without side effectsMode of action: Retinoid like effectsScience Score:



What is the science behind hydroxypinacolone retinoate?

HPR or hydroxypinacolone retinoate is an ester of retinoic acid (tretinoin; medically prescribed retinoid). There is a suggestion that HPR is as powerful as prescribed retinoids, without the unwanted side effects such as flaking, skin irritation & redness. In some countries, HPR is regulated like a prescription retinoid.

Retinoids bind to RAR & RXR receptors, in turn leading to the biological actions that include increasing cell turnover & proliferation, collagen synthesis, pigmentation & oil reduction, reduction of inflammation, & up regulation of blood vessel synthesis. This accounts for the anti-acne & anti-aging benefits of vitamin A.

The closer a molecule is to retinoic acid, the more powerful the effects. Unlike retinol, retinyl & aldehydes, HPR does not require enzymatic conversion to exert retinoid-like effects, hence all the fuss.

Is HPR better than retinol?

To date (as of 2021), there are limited papers on HPR vs retinol vs vehicle. Most papers* suggest that HPR is better than retinol, with clinical outcomes comparable to prescription retinoids like tretinoin with less side effects such as skin irritation & redness.

*Papers-research undertaken by L’Oreal. Papers that show efficacy in acne use a formulation of HPR in combination with retinol. The latest research has demonstrated a good clearance with antibacterials coupled with HPR, retinol & salicylic acid 0.5%.

What is Granactive Retinoid?

Granactive is the trade (fancy) name for HPR. This catchy name consists of 90% solvent with only 10% active ingredient. Hence if labelled as 1% Granactive, the actual concentration of hydroxypinacolone retinoate or HPR is 0.1%

What are the other alternatives?

Other options include retinol, retinyl palmitate, retinaldehyde & prescription retinoids. The most efficacious form is retinoic acid, however side effects are universally seen with prescription creams. The next most powerful topical which only requires one step conversion is retinaldehyde, followed by retinol and retinyl derivatives.

The decision to incorporate which retinoids into your skincare regimen is largely based on two factors- your end goals & importantly your skin’s irritant threshold.

Davin’s Viewpoint on HPR hydroxypinacolone retinoate

Granactive retinol results are promising however some of the studies do not make any sense. One study that shows clinical effects at Day 14. We know that for collagen synthesis, it does take 6-10 weeks for efficacy- and that is with retinoic acid (a prescription retinoid). IMO, give this a miss as there are better ingredients out there. If you are after a sensible skin care routine that includes retinoids, try this-

AM: Antioxidants such as vitamin C, E, ferulic acid, followed by SPF 50+

PM: Retinol of your choice, pulsed with tretinoin once to twice a week. AHA serum once every 10 -14 days for exfoliation. Save your money for biostimulatory injectables. They simply work.

For skin care consultations in Brisbane, book with my nurses at Cutis Dermatology. Skin care consults in Sydney, book an appointment with Louise at Dr Van Park’s clinic in the Eastern Suburbs.

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