Neurogenic Rosacea

Décolletage Solutions At A Glance

  • Best ResultsVariable
  • Treatment RecoveryVariable
  • Procedure Time1-3 minutes (Botox)
  • Skin SpecialistMedical dermatologist before procedural
  • Duration of ResultsYears +
  • AnaestheticNA
  • Back to WorkNA
  • Cost$$$-$$$$

Neurogenic Rosacea

Neurogenic rosacea is a rare subtype of rosacea characterized by persistent redness, burning, stinging, and sensitivity, often without the usual triggers like heat or spicy foods. Unlike typical rosacea, it is linked to nerve dysfunction, causing heightened pain sensations and discomfort. Patients may experience extreme sensitivity to skincare products and environmental factors, with symptoms sometimes resembling neuropathic pain.

FactsFacts on Neurogenic Rosacea

  • Neurogenic rosacea presents as burning, stinging, pain & sensitivity that is out of proportion to the clinical signs
  • In most cases the skin is red & inflamed, however this is less than with classic rosacea
  • In some cases, pimples & redness can be associated with flushing & blushing
  • Neurogenic rosacea is the most challenging subtype of rosacea to treat, often it is not responsive to usual medications
  • The mainstay of symptom relief is medical, namely SSRI & TCA tablets
  • Botox can be useful in some cases that are refractory to tablets
  • This form of rosacea rarely responds to vascular lasers

What is neurogenic rosacea?

 Neurogenic rosacea is a recently reported entity (since 2011) which forms a subset of rosacea. It is very rare, accounting for less than 0.1% of rosacea cases. It can co-exist with the normal signs of rosacea (pimples, lumps, redness, broken blood vessels, flushing, & blushing), or more commonly present as redness & flushing without lumps or bumps. 

The standout features of neurogenic rosacea are symptoms such as burning, stinging, pain, & skin sensitivity that is out of proportion to the signs of normal rosacea. 

Why is neurogenic rosacea harder to treat compared to ‘normal’ rosacea?

Inflammatory papular-pustular rosacea, redness & broken blood vessels are relatively easier forms of rosacea to treat as there are physical signs. Neurogenic rosacea on the other hand, has a paucity of physical signs, but a plethora of symptoms (itch, pain, sensitives, burning).  

For a condition that presents as symptoms, efforts are focused on reducing pain & nerve fibre messaging, followed by reducing inflammation. This means the use of tablets that target the nerves in the skin. 

What tests can be done to find out if rosacea is ‘neurogenic’ in origin?

A medical dermatologist (not me, I am a procedural dermatologist), can diagnose this condition. Most patients do not require special testing, however if you do have other signs or symptoms your medical dermatologist may-

  1. Do blood work up to exclude lupus. Occasionally they may take a biopsy to exclude lupus, not to confirm neurogenic rosacea.
  2. Exclude other conditions such as trigeminal nerve dysfunction, eg. Neuralgia or trophic syndromes. 
  3. Undertake patch testing if your symptoms include itch & sensitivities. (Let them decide).

How is neurogenic rosacea diagnosed?

A medical dermatologist can diagnose this rare, but well recognised condition. They can exclude other skin conditions that may mimic neurogenic rosacea including lupus & conditions such as trigeminal neuralgia. 

Disclaimer: I do not diagnose or initially treat neurogenic rosacea. My skill sets are in procedural dermatology, namely I Botox or laser this condition, acknowledging that medical therapy comes before procedural methods.

How to treat neurogenic rosacea?

This form of rosacea is challenging to treat as commonly, topical creams do not work. Additionally they can exacerbate the condition. 

Your dermatologist will try you on a ‘step-up’ treatment plan that goes something like this- 

  • Step one, topicals: Rozex, Azclear, Mirvaso (can flare up the condition), niacinamide. 
  • Step two, usual anti-inflammatory medications: Doxycycline, minocycline, erythromycin. 
  • Step three, possibly isotretinoin, maybe vascular lasers. 
  • Step four, probably the best outcomes for neurogenic rosacea. These tablets modify pain receptors in your skin. They include pregabapentin, gabapentin, fluoxetine, duloxetine & amitriptyline. Most will cause some degree of sedation. 

Escalation from step one to step four usually takes 6-25 weeks, depending on how quickly you & your dermatologist moves. More on how to manage your rosacea at home. 

Disclaimer: I am a procedural dermatologist, I do not prescribe medications for neurogenic rosacea. My skill sets are with injectables & laser work. 

How can you relieve symptoms of neurogenic rosacea?

Obviously seeing a medical dermatologist, neurologist, pain medicine specialist & a psychologist can help, however you may want to give these few pointers a go-

Minimise flare factors. Easier said than done. Flare factors of neurogenic rosacea include UV, heat, exercise, stress & emotional input. A medical dermatologist can help explain things in more detail, however you can find out useful tips here. 

Control the temperature of washing. Seems logical, but tepid water can help some sufferers, acknowledging that in most cases, even water on the skin can cause pain (that’s where drugs come in). 

Use cooling to relieve pain & symptoms. If you are reading this, chances are you have figured out the value of a handheld fan. Newer force-fed air movers (about $30-40 on eBay or Amazon) can provide symptom relief. Buy some aqueous cream, add some menthol (about 0.5 to2% by weight) & keep it in the fridge. Apply to skin, cool with a fan. It works in over 90% of cases, with symptom relief of seconds, minutes to hours. 

Psychotherapy. Don’t see a dermatologist to help you manage stress & emotional input, most of us are not trained to provide any sort of useful advice. Seek help from a psychologist, or alternatively meditate at home. CBD or cognitive behavioural therapy can provide powerful symptomatic relief in some.  

Topicals & cream use. Be careful what you put on, even banal creams such as Rozex, Soolantra, niacinamide & azelaic acid can flare up your symptoms. Learn how to patch test any form of topicals. 

More on tips for rosacea prone skin. 

How should you approach skin care if you have neurogenic rosacea?

Cautiously. Rosacea patients have extra-sensitive skin. For neurogenic rosacea patients, multiply this sensitivity by a factor of 10. Understand patch testing before you attempt to apply things on your face. More on how to patch tests later. 

For true cases of neurogenic rosacea, topical therapy usually provides little relief. In some cases it can even worsen stinging, burning, itch & pain. In the minority of cases, you can try- 

Niacinamide 5-10% Vitamin B3 can reduce inflammation, redness as well as improve your skin’s barrier function. Apply once to twice daily. 

Rozex or Metronidazole gel. This is better tolerated in classic rosacea. You can obtain this via your GP or over the counter in Australia. 

Azelaic acid 10-20%, azelaic acid can reduce inflammation as it is relatively gentle on the skin. Azclear is a good brand. 

Tocopherol or vitamin E is a fat soluble vitamin. It is a powerful antioxidant that does not irritate skin. 

Tacroliumus can be considered under the supervision of a dermatologist. It can reduce inflammation, but conversely may cause more stinging & burning. 

Sodium sulfacetamide & sulfur is another formulation that is more useful for inflammatory rosacea over neurogenic cases. You can leave this formulation in the fridge as it may provide a reduction of symptoms in some neurogenic cases. 

Aqueous cream & menthol can be considered in some cases of neurogenic rosacea. Keep this in the fridge, apply on skin then use a fan to help cool down skin. It works surprisingly well. 

More on how to use skin care for super sensitive skin.

Davin’s viewpoint on Managing Neurogenic Rosacea

Research the meaning of ‘research’ before labelling yourself as having neurogenic rosacea. Read the pharmacology papers, the differential diagnosis and clinical aspects of managing skin, psychology & nerves before opening with the line ‘….according to my own research.’ It takes many hours of reading & cross referencing, before putting a sentence down.

Don’t get me wrong, this page is not designed to get you to see me, nor is it a way to sell you a treatment, it simply exists to cut through the crap & provide you with a solution in as little appointments as possible. On the contrary, try everything else before going down the procedural route as –

  1. Botox does not ALWAYS work 2. Botox can only be used in some areas. Place it too concentrated or in the wrong areas & you will look like a stroke sufferer for 3-6 months, even longer if Relfydess is used, instead of Botox. 3. Lasers, even vascular lasers with cooling systems work best if there is redness &  inflammation. Besides, there is a small chance that lasers can worsen pain for variable periods of time. 

Here is a summary as to how to navigate this debilitating, poorly understood & rare condition. 

  1. See a medical dermatologist for a diagnosis. Don’t diagnose this yourself as you have no idea where you lie on the symptomatic scale. You may think symptoms are significant, when in reality they may be normal. The converse applies. A dermatologist can exclude other conditions such as inflammatory conditions such as lupus. Forget your ‘research’, leave it to them. 
  2. Don’t underestimate the fluffy bits; ie. rosacea tips. Even if each tip gives you 1% symptom relief, a culmination of 20-30 tips may give you enough symptom relief to not go on medication or at least have a lower dose of meds. 
  3. Follow advice, as dished out by your dermatologist. Most should be super clear on how to manage this rare condition (when I was doing medical dermatology I would see at least 6-8 cases annually, so in reality if one has been practicing for 20 years, it really is not that rare). Medications can make a difference in most cases. My go to is amitriptyline as, in my view, it works better than gabapentin or pregabapentin (Lyrica). In the past (remember I don’t prescribe now as I am procedural), I started patients at 5 to 10 mg nightly. It does cause drowsiness, so titrate your dosing time. Increase by 5 mg every 1-2 weeks. Most won’t need more than 25 mg, though your physician may push up to 50-75 mg in some cases. 

Failing that duloxetine (a newer form of Prozac) can work. My advice is to titrate both Endep & duloxetine. The latter can also help with flushes associated with menopause. 

  1. Talk to someone. Unlikely it’s going to be a dermatologist as most have 5-7 minute appointment slots, acknowledging that some dermatologists like practicing psycho-dermatology. Seek help from a psychologist with a special interest in pain management early. They will teach you how to deal with pain & provide you with CBT techniques, improving your psyche & quality of life. Don’t rely solely on a physician. 
  2. Escalate to high level pain management with an anesthetist or pain specialist. These smart folk can add medications that are outside the box. Your GP or dermatologist will refer you accordingly. 
  3. Meditate, do yoga, enjoy life & stop feeling sorry for yourself. It makes a huge difference when it comes to managing neurologic disorders as well as complex pain management syndromes, OCD, and chronic fatigue syndrome. 
  4. I’m the last person to see for neurogenic rosacea, as my practice window for this condition is procedural, namely trial of Botox. I do perform lasers if there is redness (objective not subjective). Without a good target to hit, the chances of laser working is slim. 

Disclaimer: My role in the management of rosacea is a very narrow one, namely my job is procedural. I treat end stage rosacea including phyma patients. I also employ lasers to reduce inflammation & redness. Lasers are not monotherapy. Ideally you should be under the guidance of a medical dermatologist as treatments with topicals & orals are frequently needed. This especially applies to the management of neurogenic rosacea, at least for the first & second line treatments.

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